Genome Architecture and Dynamics 2019
International Summer School and Workshop
July 12 – July 19, 2019
About This Workshop
The development of a quantitative theory of how cells respond to their environment and regulate their function is one of the most challenging and important problems in science. It has become clear that the structure an dynamics of the genome plays a large part in this response.The effort to understand genome structure and its functional consequences has attracted scientists and engineers from diverse research fields.
This summer school and workshop will focus on the biophysics and biochemistry of eukaryotic cell nucleus and especially the genome contained therein. Approximately 60 students and postdocs and an equal number of scientists will participate in the meeting. It is our hope and expectation that participants will attend all 7+ days of the workshop.
Leading scientists will give lectures during the first two days of the workshop. Lectures will present polymer models of chromosome organization and dynamics, statistical physics of polymer systems, theoretical foundations of phase separation in such systems, and ideas regarding the coupling between chromosome structure and gene expression.
During the next four days, research talks and discussions will address nuclear mechanics and chromosome dynamics, DNA looping and extrusion, the biophysics of gene regulation, replication, chromosome segregation, transcription bursting vs noise, splicing of premature RNA and how transcriptional noise is connected to splicing. The meeting will address the structural transitions of the chromatin across the cell cycle, RNA and DNA induced liquid-liquid phase transitions in subcellular organization and their role in gene regulation and DNA repair.
In addition to the school and workshop there will be a mini workshop on international funding at the interface between physics and biology in which several European funding agencies will be represented.
Anastas Gospodinov, NAS, Bulgaria
José Onuchic, Rice University, USA
Catherine Villard, L’Institut Curie, France
Herbert Levine, Northeastern University, USA
Iva Ugrinova, NAS, Bulgaria
Phillip Sharp, MIT, USA
Peter Wolynes, Rice University, USA
Zan Luthey-Schulten, UIUC, USA
Taekjip Ha, JHU, USA
Leonid Mirny, MIT, USA
Bill Earnshaw, University of Edinburgh, UK
Marco Foiani, University of Milan and IFOM, Italy
Marcelo Nollmann, CNRS/INSERM, France
Cees Dekker, Technical University of Delft, Netherlands
Anthony Hyman, Max Planck Institute of Molecular Cell Biology & Genetics, Germany